• I-15 – managed lanes segment of Escondido Freeway in San Diego
  • I-30 – Dallas-Fort Worth Tollway (formerly tolled; originally signed as I-20)
  • I-35 – Kansas Turnpike
  • I-39 – Northwest Tollway – Rockford, IL
  • I-44 – Oklahoma: H.E. Bailey Turnpike, Turner Turnpike, Will Rogers Turnpike
  • I-64 – West Virginia Turnpike
  • I-65 – Kentucky Turnpike (formerly tolled)
  • I-70 – Pennsylvania Turnpike (on shared alignment with Interstate 76), Kansas Turnpike
  • I-75 – Alligator Alley (Florida); Mackinac Bridge (Michigan)
  • I-76 (Eastern) – Ohio Turnpike, Pennsylvania Turnpike, Walt Whitman Bridge
  • I-77 – West Virginia Turnpike
  • I-78 – Delaware River Bridge (westbound only), Holland Tunnel (eastbound only)
  • I-80 – Delaware River Bridge (westbound only), Ohio Turnpike, Indiana Toll Road, Tri-State Tollway, Carquinez Bridge (northbound only), San Francisco-Oakland Bay Bridge (westbound only)
  • I-84 – Hudson River Bridge (eastbound only)
  • I-87 – New York Thruway
  • I-88 – Illinois East-West Tollway
  • I-90 – Massachusetts Turnpike, New York Thruway (Mainline and Berkshire Section), Ohio Turnpike, Indiana Toll Road, Chicago Skyway, Illinois Northwest Tollway
  • I-93 – F.E. Everett Turnpike
  • I-94 – Tri-State Tollway
  • I-95 – Fort McHenry Tunnel, John F. Kennedy Memorial Highway (including both the Maryland Northeastern Expressway and the Delaware Turnpike), Pennsylvania Turnpike (future), New Jersey Turnpike, George Washington Bridge (eastbound), New England Thruway, Connecticut Turnpike (formerly tolled), New Hampshire Turnpike, Maine Turnpike
  • I-910 – Crescent City Connection/Greater New Orleans Bridges
  • I-335 – Kansas Turnpike
  • I-355 – North-South Tollway
  • I-470 – Kansas Turnpike
  • I-275 – Sunshine Skyway Bridge
  • I-276 – Pennsylvania Turnpike
  • I-476 – Pennsylvania Turnpike Northeast Extension
  • I-676 – Ben Franklin Bridge (westbound only)
  • I-278 – Triborough Bridge, Goethals Bridge (eastbound only), Verrazano Narrows Bridge (westbound only)
  • I-478 – Brooklyn Battery Tunnel
  • I-678 – Whitestone Bridge
  • I-580 – Richmond-San Rafael Bridge (westbound only)
  • I-680 – Bencia-Martinez Bridge (northbound only)
  • I-185 – Southern Connector (Greenville, SC)
  • I-287 – New York Thruway section, including Tappan Zee Bridge (eastbound only)
  • I-190 – Niagara Section of the New York Thruway
  • I-294 – Tri-State Tollway
  • I-295 – Delaware Memorial Bridge (southbound only)
  • I-295 – Throgs Neck Bridge
  • I-395 – Connecticut Turnpike (formerly tolled)
  • I-495 – Falmouth Spur of the Maine Turnpike
  • I-495 – Lincoln Tunnel between New Jersey and New York – former route (now NJ 495/NY 495)
  • I-495 – Queens Midtown Tunnel under East River in New York City – former route (now NY 495)
  • I-695 – Francis Scott Key Bridge
  • I-895 – Harbor Tunnel (Baltimore)