I-65 through I-69 and Signed Branch Routes

Interstate South/West Terminus North/East Terminus
65 Mobile, AL Gary, IN
165 AL Downtown Mobile Prichard
165 KY Bowling Green Owensboro
265 IN/KY New Albany, IN Worthington, Louisville, KY
465 IN Beltway – Indianapolis
565 AL Decatur Huntsville
865 IN Royalton Zionsville
66 Middletown, VA Washington, DC
68 Morgantown, WV Hancock, MD
69 Indianapolis, IN Canadian Border at Port Huron, MI
69 MS Tunica Hernando
69C TX Pharr Edinburg
69E TX Brownsville Corpus Christi
69W TX World Trade Bridge Laredo
169 TX Brownsville Brownsville
269 MS/TN Hernando, MS Arlington, TN
369 TX Texarkana Tenaha
469 IN Fort Wayne Fort Wayne
I-65 south at I-20/59 - Birmingham, AL
Interstate 65 south at I-20/59 in Birmingham, Alabama. This interchange is locally known as “Malfunction Junction” due to left exit ramps. 04/14/13

The exchange between I-20/59 and I-65 in Birmingham is unique in that the roadways of both freeways switch sides in order to make the connections with one another. The previous interchange joining I-95/695 on the east side of Baltimore was designed similarly until the Express Lanes were constructed from 2006 to 2014.

IH 2 east at IH 69C - Pharr, TX
Approaching the south end of Interstate 69C and U.S. 281 on IH 2 east in Pharr, Texas. Photo by Jeff Royston (08/19/13).

Interstate 69C is a Congressionally Designated route. As such it is exempt from the AASHTO numbering convention in that no Interstate shall be designated with a lettered suffix.