Interstate 81 Branch Routes

I-40 West at Interstate 81 near Dandridge, Tennessee Interstate 81 near Dandridge, TN ↔ Canadian International Border – Alexandria Bay, NY I-81 South at former Interstate 181 near Colonial Heights, Tennessee Former Interstate 181 Tennessee Kingsport, TN The beginning of Interstate 381 North in Bristol, Virginia Interstate 381 Virginia Bristol, VA ↔ Bristol, VA I-81 South at Interstate 481 in Syracuse, New York Interstate 481 New York Syracuse, NY ↔ North Syracuse, NY I-81/U.S. 220 South at Interstate 581 to Roanoke, Virginia Interstate 581 Virginia Roanoke, VA ↔ north of Roanoke, VA I-81 South at Interstate 781 in Pamelia, New York Interstate 781 New York Pamelia, NY ↔ Fort Drum North Gate – Le Ray, NY