Interstate 680 branches north from I-76 at Beaver Township in Mahoning County to join the Ohio Turnpike with the city of Youngstown. The freeway loop runs north between Boardman and the city of Struthers. Entering Youngstown at the Lansingville neighborhood, I-680 makes a sweeping curve west to South Avenue and then turns north to the inner belt freeway system encircling Downtown.
U.S. 62, U.S. 422 and Ohio 193 represent the eastern half of the inner loop, joining I-680 with Youngstown State University and northern neighborhoods of the city. Turning westward to I-80, Interstate 680 meets Ohio 711, a freeway connector linking with both Ohio 11 north to Ashtabula and I-80 east to Sharon, Pennsylvania. I-680 west defaults onto I-80 west at the separation with Ohio 11 south by Mineral Ridge.