Mississippi Highway 15 formerly overlapped with all of Interstate 110 until March 2009. Opening at that time, construction of the Biloxi – D’Iberville Scenic Expressway included a new alignment for MS 67 to the southeast and a trumpet interchange with MS 15. As a result, MS 15 was truncated to the MS 67, with MS 67 extended south over former MS 15 to the cloverleaf interchange with I-10 and I-110. MS 15 previously ran along Caillavet Street and Central Avenue to the east of I-110 through Biloxi and D’Iberville.
Making landfall on August 29, 2005, Hurricane Katrina devastated Biloxi, Gulfport and the Mississippi Gulf Coast. Long segments of U.S. 90 were destroyed in the process, but damage to Interstate 110 was minimal and the freeway quickly reopened.
Construction started in 2013 on Phase I of the Interstate 10/110 Interchange Improvements project at D’Iberville. The $29.7 million project included new interchanges along I-10 at Galleria Parkway (formerly D’Iberville Boulevard) and Lamey Bridge Road. Work also realigned the loop ramps joining I-10 and I-110 while adding a collector distributor roadway along I-10 east and auxiliary lanes. Costing $11.4 million, Phase II started in March 2014. This added a half diamond interchange between Big Ridge Road, since renamed as an extension of Popps Ferry Road, and I-110.2
The c/d roadway from Interstate 10 east to I-110 opened on January 21, 2015.3 The Diverging Diamond Interchange (DDI) at Galleria Parkway opened to traffic following a ribbon cutting ceremony on June 2, 2015.4 The new ramps between I-110 and Popps Ferry Road opened on September 3, 2015, with a formal ribbon cutting ceremony wrapping up all work on the two phase project.5 A flyover remains planned to replace the loop ramp connecting Interstate 10 west with I-110 south. Lack of funding delayed the project until at least 2025.5
A separate four phase project focused on the replacement of the at-grade intersection of MS 67 with Promenade Parkway / Sangani Boulevard just beyond the north end of Interstate 110. Work on the $7.3 million project started in March 2012. The congested intersection was replaced with a folded diamond interchange and a 17 foot high overpass spanning MS 67. The ramps to MS 67 opened on July 25, 2013, while side work on Sangani Boulevard continued through November 2013.6
Most of the sign assemblies along Interstate 110 on the Walter L. Nixon Memorial Bridge over the Back Bay of Biloxi and the elevated freeway through Biloxi were removed by November 2015. Overall 20 overhead signs were taken down by the Mississippi Department of Transportation (MDOT) as part of sign replacement project underway throughout southeast Mississippi. The project replaced sign bridges with cracked and substandard trusses with new assemblies adhering to current hurricane standards.7