Interstate 110 links Downtown Pensacola with I-10 at Ferry Pass beyond the Pensacola city line.
Interstate 110 facilitates traffic from I-10 south to Downtown Pensacola and the Pensacola Bay Bridge (U.S. 98) south to Gulf Breeze and Pensacola Beach. The freeway serves commuters and Pensacola Naval Air Station traffic via busy interchanges with Fairfield Road (SR 295), Brent Lane (SR 296), Airport Boulevard (SR 750) and connections with Davis Highway (SR 291) just east of the north end at I-10.
The following are key dates in the history of Interstate 110 in Florida:2
- 1968 – Interstate 110 first proposed to extend further south to what was then the city limits of Pensacola.
- 1969 – Interstate 110 constructed from Maxwell Street north to I-10 (first segment to open).
- 1978 – Interstate 110 opened from Gregory St. north to Maxwell Street. I-110 is now complete.
Work completed in July 2009 expanded the freeway to six overall lanes from the Maxwell/Jordan Street half diamond interchange northward to the SR 742 (Creighton Road) overpass. Included in the $58 million rebuild of the freeway was the addition of a new split-diamond interchange with Airport Boulevard (SR 750) and conversion of the diamond interchange with SR 295 (Fairfield Drive) to a parclo interchange. This work coincided with the I-10/110 project from early 2007 onward.
Costing $76 million, the I-10/110 project was completed in Fall 2008. Construction widened Interstate 10 to six lanes from east of the Old Palafox Highway (Escambia County Road 95A) overpass to a point beyond the Davis Highway (SR 291) interchange (Exit 13), and six-laning of Interstate 110 from I-10 southward to just north of the Airport Road overpass. Improvements at the trumpet interchange joining I-10/110 included the addition of a flyover ramp from I-10 west to I-110 south and collector distributor roadways separating local and through traffic between I-10, I-110 and SR 291. SR 291 was also widened to six lanes from I-10 south to University Town Plaza (formerly University Mall) as well. Construction began in 2002.
Associated with the I-10/110 project was the construction of a new Creighton Road overpass over Interstate 110. This new alignment extended the five lane arterial to Hilburn Road where the state road reunites with the original SR 742 alignment along Burgess Road. SR 742 comprises a five lane arterial east from Hilburn Road to SR 289 (Ninth Avenue). A widening of Creighton Road between Davis Highway and Ninth Avenue was completed by 1996. Future plans, though not yet funded by the state legislature, call for extending Creighton Road further west to U.S. Highway 29.