Business Loop I-55 - Cape Girardeau and Jackson

Business Loop I-55 through Cape Girardeau and Jackson could be considered two separate routes. The 15.70 mile alignment arcs east through Cape Girardeau from Exit 93 alongside U.S. 61 (Kingshighway) to a busy retail area centered around the intersection with William Street (Route K). Missouri Route 34 combines with Kingshighway north from Route 74, as the three routes turn westward onto a divided highway and cross both Interstate 55 and the Jackson city line.

Following Jackson Boulevard west from Exit 99, Business Loop I-55, U.S. 61/Route 34 constitute a five lane boulevard northwest to Route 25 (Hope Street). There U.S. 61 and Business Route 55 turn north through Downtown, navigating along Hope, Washington and High Streets to northern reaches of the city. Business Loop I-55 reduces to two lanes on the return to I-55 at Exit 105.

The Jackson portion of this business route was approved by the American Association of State Highway and Transportation Officials (AASHTO) on April 9, 1994.