Business Loop I-49 - Neosho

Business Loop I-49 in Neosho begins at a rural diamond interchange (Exit 20) with Highway AA southwest of the Neosho city limits. The initial leg of the business route stems east to Missouri Route 59 (old U.S. 71) at McElhany over a locally maintained roadway. Combining with Route 59, Business Loop I-49 leads north past Neosho Hugh Robinson Memorial Airport (EOS) and Neosho Industrial Park (part of which was formerly Fort Crowder) to U.S. 60.

Missouri Route 59 turns east alongside U.S. 60 across south Neosho, while Business Loop I-49 briefly combines with U.S. 60 Business (Neosho Boulevard) northward. The U.S. 60 business loop angles northeast to the Neosho city center while Business Loop I-49 remains along old U.S. 71 to the west. Route 86 joins the business route from Harmony Street for the return to Interstate 49 at Exit 27.

The 9.74 mile loop was formally established on December 12, 2012 with all of I-49 in Missouri.