Business Loop I-44 - Joplin, Duquesne and Duenweg

Business Loop I-44/Route 66 east of Route 249 near Duenweg, MO — Business Loop I-44/MO 66 heading east to Duenweg. 05/04/12

Route 249 north at Business Loop I-44 near Joplin, MO — Route 249 begins ahead of Business Loop I-44/Route 66 at its first interchange east of Joplin. March 2009

Business Loop I-44/Route 43 north at Route 66 in Joplin, MO — Business Loop I-44 ends an overlap with Route 43 (Main Street) and combines with Route 66 along E 7th Street between Downtown Joplin and Duenweg. 05/04/12

Business Loop I-44 travels 11.84 miles in an L-shaped route through Newton and Jasper Counties in southwest Missouri. The route combines with Missouri Route 43 north from Exit 6 along Hearnes Boulevard north to 32nd Street along a divided arterial. Main Street (old U.S. 71 Business) takes over as a commercial boulevard to Downtown Joplin and 7th Street. The remainder of the route travels east along Route 66 (Historic U.S. 66) to Business Loop I-49 near Northpark Mall, northern Duquesne, the freeway along Route 249 and across the city of Duenweg. The business route ends at a wye interchange (Exit 15) with I-44 adjacent to Cimarron Road.

Updated August 1, 2026