Business Loop I-25 - Buffalo

Also signed as U.S. 87 Business, Business Loop I-25 travels 3.4 miles overall as it connects Interstate 25 with Downtown Buffalo and U.S. 16 west across the Bighorn Mountains. The business route begins at Exit 298 from Interstate 25. The pair enter the historic district of Buffalo following Main Street, which crosses Clear Creek near the historic Occidental Hotel and comes within two blocks of Buffalo City Park. The city park is notable for having what is billed as the largest outdoor swimming pool in Wyoming, and it is free for the public to use the pool during operating hours.

Near the Johnson County Courthouse, Business Loop I-25/U.S. 87 Business meet U.S. 16 at Fort Street. Main Street carries the three routes northward between Fort Street and Hart Street. Once at Hart Street, U.S. 16 again turns east along with eastbound Business Loop I-90, as Business Loop I-25/U.S. 87 Business north are joined by westbound Business Loop I-90. From this point northward along Main Street, the business route signage tends to favor the return to I-90 with trailblazers showing "To Interstate 90" and North U.S. 87 Business.

The three business routes end at Exit 56 A on Interstate 90 as the northward extent of Business Loop I-25 matches the north end of Interstate 25, which is located just to the east at Exit 56 B.

Heading southbound, Business Loop I-25/90 are cosigned along with U.S. 87 Business from the point they depart Interstate 90 at Exit 56 A to Hart Street, where the business route meets U.S. 16 east and the two Interstate business loops separate.