Interstate 24 has only one business loop, in Paducah, Kentucky.
Business Loop I-24 constitutes a 11.4-mile loop through the city of Paducah between Exits 4 and 11. The loop overlays U.S. 60 east along Hinckleville Road to Park Avenue and U.S. 60 Business (3rd Street) through Downtown. Following U.S. 60 Business (Wayne Sullivan Drive), Business Loop I-24 traverses an industrial area along side the Tennessee River before turning south to become Kentucky 1954 (John L. Puryear Drive) on the return to Interstate 24.
The Paducah Business Loop was originally signed as "Downtown" Loop I-24, similar to signs for the Interstate business routes in Sioux Falls, South Dakota.
The alignment changed with the completion of John Puryear Parkway, a new five-lane arterial for KY 1954, north from I-24 at Husband Road to U.S. 60 and 62. Prior to 1998, Business Loop I-24 overlapped with U.S. 60-62 southeast to U.S. 68 and Exit 16.1